Tuskegee was founded and laid out in 1833 by General Thomas Simpson Woodward who fought in the Indian Wars under Andrew Jackson. It was probably named after an Indian tribe, the Taskigis, living in this section, General Woodward built the first home in town. It was partially destroyed by fire and rebuilt by Mr. William Campbell. The first home on the square was built by Mr. James Dent. Tuskegee was the home of the Taskigis, Channuanugee, Chehaws and Tallassee Indian tribes.